Doxepin – What It Is and How It Works

Doxepin is a pill that belongs to the tricyclic antidepressant family. Even though it was first made for depression, doctors now use it for a few other things too, like severe itching, anxiety, and trouble sleeping. It works by balancing certain chemicals in your brain, which helps calm mood swings and eases uncomfortable skin itching.

Typical Doxepin Dosage

For depression, adults usually start with 25 mg once a day, then may go up to 75 mg or 100 mg depending on how they feel. When it’s prescribed for itching (often under the brand name Silenor), the dose is lower—usually 3 mg to 6 mg taken at bedtime. Sleep problems also use the low‑dose version. Most tablets are taken once daily, preferably in the evening because doxepin can make you drowsy. If you miss a dose, just take it as soon as you remember unless it’s almost time for the next one—don’t double up.

Common Side Effects & Who Should Avoid

Typical side effects are dry mouth, constipation, blurred vision, and a bit of dizziness. Some people feel weight gain or a fuzzy brain, especially when they first start. If you notice a fast heartbeat, severe rash, or swelling of your face, get medical help right away—those can be signs of a serious reaction.

People with a history of heart problems, recent heart attack, or uncontrolled high blood pressure should talk to their doctor before starting doxepin. The drug can also interact with other medicines like certain antidepressants, antihistamines, or alcohol, making drowsiness worse. Always list every prescription and over‑the‑counter pill you take.

Pregnant or breastfeeding moms need extra caution. Doxepin passes into breast milk, so doctors usually suggest a different treatment unless the benefits outweigh the risks.

To keep side effects low, stay hydrated, chew sugar‑free gum for dry mouth, and add a little more fiber to your diet if constipation shows up. If you feel unusually sleepy during the day, avoid driving or operating heavy machinery until you know how the medication affects you.

When you start doxepin, give your body a week or two to adjust. If you don’t feel any improvement after that, or if side effects become unbearable, reach out to your healthcare provider. They might lower the dose, switch the timing, or try a different drug.

Never stop taking doxepin abruptly, especially if you’ve been on it for months. Stopping suddenly can cause withdrawal symptoms like nausea, anxiety, or flu‑like feelings. If you need to quit, your doctor will taper you off slowly.

Bottom line: doxepin can be a solid option for depression, itching, or sleep problems when used the right way. Keep track of how you feel, follow the dosing schedule, and stay in touch with your doctor for any changes. With these simple steps, you’ll get the most benefit while keeping risks low.