Male Infertility Medication: What Works, What Doesn't, and What to Ask Your Doctor

When male infertility medication, drugs prescribed to improve sperm production, motility, or hormonal balance in men struggling to conceive. Also known as fertility drugs for men, it is not a one-size-fits-all fix—it’s a targeted response to underlying causes like low testosterone, blocked ducts, or hormone imbalances. Many men assume infertility is always a woman’s issue, but nearly half of all infertility cases involve male factors. That means male infertility medication isn’t rare—it’s often the missing piece in a couple’s journey to parenthood.

These medications don’t just boost sex drive. They work on the body’s plumbing: the testes, the pituitary gland, the hormones that tell sperm to grow. For example, if your body isn’t making enough luteinizing hormone (LH) or follicle-stimulating hormone (FSH), drugs like clomiphene or human chorionic gonadotropin (hCG) can kickstart production. If low testosterone is the root cause, replacement therapy might be recommended—but only after testing, because too much can backfire and kill sperm. And then there are the less obvious players: antioxidants like CoQ10, vitamin D, and even certain blood pressure meds that accidentally help sperm count by improving blood flow. These aren’t magic pills. They’re tools, and they only work when matched to the problem.

What you won’t find in most drug ads are the real-world trade-offs. Some men gain weight. Others get mood swings. A few see no change at all. That’s why knowing your numbers—sperm count, motility, morphology, hormone levels—is non-negotiable. A doctor who just hands you a script without testing is doing you a disservice. The best results come from pairing medication with lifestyle tweaks: cutting alcohol, quitting smoking, avoiding hot tubs, and managing stress. You can’t out-drug a bad diet or chronic sleep loss.

And while you’ll see tons of online stores selling testosterone boosters, over-the-counter supplements claiming to raise testosterone and improve fertility. Also known as natural male fertility supplements, it often contains herbs like ashwagandha, fenugreek, or zinc, but rarely has clinical proof behind them. Stick to FDA-approved options first. Supplements might help as a side support, but they’re not replacements for real medicine. The same goes for ED pills like sildenafil or vardenafil—these help you get an erection, but they don’t fix low sperm count. Confusing the two is common, and it leads to wasted time and money.

What’s clear from the real cases? Men who track progress, ask questions, and stick with treatment for at least three to six months (the time it takes to make new sperm) see the best outcomes. If one drug doesn’t work, there’s usually another path. You’re not broken. You just need the right map.

Below, you’ll find real comparisons of medications used for male infertility—from the science-backed prescriptions to the common alternatives men actually try. No fluff. No hype. Just what works, what doesn’t, and what to watch out for.