Combination NTI drugs offer powerful treatment for complex conditions but face major barriers to generic availability. With no approved fixed-dose combinations in the U.S., patients face higher costs, increased monitoring, and greater risk of adverse events after generic switches.
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When doctors write 'Do Not Substitute' on a prescription, it's not about cost - it's about safety. Learn why brand-name drugs are sometimes the only safe choice for patients on narrow therapeutic index medications, biologics, or those with prior adverse reactions to generics.
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